This week's HND piece explores a phenomenon that is more widespread than most people think. For starters, some estimates peg the extent of this practice at around 20 percent of all prescriptions written.
Not to make too fine a point of it, but since the use is off-label, by definition, there is little if any conventional scientific validation of these drug indications. Of course, given the state of science these days, as well as the politics of drug approvals, some of the best-selling FDA-approved drugs don't have much science behind them, either.
For the most part, off-label use is based on plenty of anecdotal evidence that such practices are safe and effective—unless the off-label use is strictly driven by cost. Sadly, that is definitely the case regarding the off-label use of Avastin®—a cancer drug—instead of Lucentis®, for the treatment of neovascular (wet) age-related macular degeneration. Lucentis carries an FDA approval for this indication, and Avastin does not.
To make matters worse, part of the reason that Avastin is cheaper than Lucentis is that practitioners are compounding individual doses of it from bulk supplies, and many cases of infection are attributable to such activities. As you might suspect, these eye infections can be quite serious.
But, as we have said so many times in the past, the very most important thing in health care—on a superficial level, anyway—is cost, so by all means keep on compounding. I guess such practices are are whole lot easier than actually addressing the real sources of out-of-control health care costs.
Some day, we can talk about the outrage whereby at least 40 percent of all radiology is done for defensive purposes, only. Think that might be driving up health care costs? Then there's the indisputable fact that hospital residents (except for surgeons and anesthesiologists) spend at least 70 percent of their time on paperwork. For primary care docs is can be as high as 90%. Trust me, these factoids are only the tip of the proverbial iceberg. Eliminate waste and fraud, and you can save at least half of the current health care budget. Probably much more than that.
Read the complete article.